Introduction

1. History of mechanical support for the failing heart
   

2. Intention of mechanical support and indications
   
3. The place of mechanical support in the treatment of chronic heart failure
   
4. Incidence and outcome of mechanical support
   
5. Types of mechanical support
   
6. Technical specifications of rotary blood pumps
   
7. Problems of miniaturized rotary blood pumps adressed in this work

Methodology

1. In vitro model

   1. Static in vitro model
      
   2. Dynamic in vitro model
2. In vivo model
   1. The animals
      
   2. Anesthesia
      
   3. Surgical preparation
      
   4. Hemodynamic measurements
      
   5. Heart failure model
      
   6. Organ and myocardial perfusion
3. Data analysis

Results and discussion

1. The heart-device interaction

   1. The in vitro results
      
   2. The interaction hypothesis
      
   3. The in vivo results
      
   4. The in vitro adjustment
      
   5. General discussion
2. Organ and myocardial perfusion
   1. The devices used
      
   2. Experimental protocol
      
   3. Hemodynamic changes, unloading and contractility
      
   4. Peripheral organ perfusion
      
   5. Myocardial perfusion
      
   6. Discussion
3. The rotary blood pump for chronic use
   1. The pump
      
   2. The experimental set-up
      
   3. The pilot experiment: inflow cannulation
      
   4. Hemodynamic performance
      
   5. Hemolysis and thrombosis
      
   6. Adaptation of the pump design
      
   7. Discussion

Conclusions and outlook
Summary
Samenvatting
References

• 876 | Specialistische geneeskunde: algemeen

• Number of pages: 120
• Width: 16 cm
• Height: 24 cm

• Bart Meyns, Author (all publications from this author/editor with Leuven University Press)